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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in adults with a body mass index (BMI) in excess of 27, provided they also are afflicted by weight-related health concerns such as Tupe2 diabestes, high cholesterol and/or hypertension (blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so that as an aid to smoking cessation treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle that features a reduced-calorie eating and working out, Contrave provides another treatment choice for chronic weight-loss for people who are obese or are overweight and have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that contains a reduced- calorie diet and regular exercising. Results from a clinical trial that enrolled patients without diabetes showed that patients had the average weight loss of 4.1% instead of participants who were given placebos) within a 12- month period, while another study involving patients with diabetes type 2 symptoms had a normal weight loss of 2% over treatment with placebo at 12 months.

Using two separate drugs to shed pounds can be very effective you can find combinations before the FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you should err assisting caution and allow the FDA do its job and demand some investigation be done so your public recognizes the side effects and risks of the medications before we take them. Keep in mind that drug companies have been in business to generate money and that they would say anything to keep people on their medications.

Researchers discovered that participants investing in this drug for a year, dropped excess weight within 4 weeks and have kept the extra weight off through the 56 weeks from the study. Contrave is a combination in the drugs naltrexone and bupropion, which generally seems to reflect a brand new trend of weight-loss drugs which are made up of several active ingredient, that might make them more effective and safer.

Combo-pilling will be the newest fad or better yet the newest ahead under scrutiny and thus it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular could be the fact that at the time of right now there are not any long term prescription weightloss pills that have been licensed by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be approved by the FDA.

Seizures certainly are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug can also raise blood pressure and heartrate, and must not be used in those with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure level and heartbeat and must stop used in patients with uncontrolled high blood pressure, along with by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients using a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients for the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking.


'The intent of the bill is always to give police force and district attorneys an instrument to address illicit drug use among women that are pregnant through treatment programs," Tennessee governor Bill Haslam said.